|
Please use the menu below to discover
more about ID Education
About ID Education.org
ID Education's mission is to deliver high
quality and highly relevant, CPD approved, educational programs
to clinicians, pharmacists and nurses, through experts in
their field of knowledge, for the benefit of people living
with HIV.
ID education Organistaion information:
Professor Clive Loveday: Founding Member
and Chairman
Dr Stephen Taylor: Founding
Member and Secretary
For information on how to contact us pleae
see the 'Contact' section.
About Professor
Clive Loveday
Professor Clive Loveday trained as a scientist
with a first degree in microbiology and pharmacology (1969)
and a doctorate microbiology/immunology from The Middlesex
Hospital, University of London (1973). He trained as a medical
practitioner at The Middlesex Hospital and graduated in
1980, by which time he had also gained a wide experience
in clinical research, and had published 13 peer-reviewed
papers during his studies.
He undertook a higher professional training
in primary health care (1982-4) during which time the HIV/AIDS
pandemic was identified and he determined to specialise
in this field.
He was appointed Lecturer in HIV/AIDS
at The Middlesex Hospital/UCL in 1985 and with Professor
Weller and Dr Carne undertook the clinical care of a large
cohort of patients with HIV/AIDS. During this period he
collaborated in a number of sentinel studies: the first
UK AZT monotherapy trial(1986), the efficacy of gamma interferon
in chronic HBV infection and associated sero-reversion (1987),
the use of long-term gancyclovir maintenance therapy to
control clinical CMV retinitis progression (1987), eight
anonymized sero-epidemiology surveys between 1982 and 1993
in the London GUM population defining a rising prevalence
of HIV/AIDS in gay men, infection of heterosexual patients
and the appearance of HTLV-1, HIV-2 and HCV in these populations,
identifying the clinical markers defining disease progression
in HIV/AIDS, the involvement of circulating immune complexes
in HIV/AIDS, the role of humoral antibodies in HIV-1 pathogenesis
and the progressive increase in complement levels associated
with disease stage, and the role of p24Ag as a surrogate
marker of antiretroviral drug response.
In 1988 to expand his clinical research
experience he moved to the Division of Virology in The Middlesex
Hospital as District AIDS Officer funded by the Wellcome
Trust. He led a team of four scientists in a clinical research
program evolving new technologies to support patient care.
Initially he developed novel-ELISA assays to quantify p24
and RT antigens and antibodies. Then applied these four
assays in patient cohorts to determine the interrelationship
of these markers and their predictive value in defining
disease stage and progression.
The development of PCR provided new and
exciting options for the real-time study of microbial infections.
His research group developed applications for PCR to support
HIV patient care. They developed the first quantitative
viral load and resistance assays in the world to be used
in the clinical management of patients with HIV/AIDS (1990).
These assays were used widely in MRC and
commercial clinical trials to provide unique efficacy data,
including:
- MRC Concorde, Alpha and Delta trials
(1990-94)
- Glaxo NUCB3001/2 studies of the efficacy
of AZT/3TC relative to AZT alone in drug naïve and
experienced patients
- in a range of confidential monotherapy
evaluations for pharmaceutical companies.
In 1993/4 the group used the technology
to demonstrate the rapid decline in plasma HIV-1 RNA load
to nadir within days during anti-retroviral monotherapy
which led to an understanding of the dynamics of HIV-1 turnover.
Further, he defined rates of loss of wild-type viruses associated
with sub-optimal anti-retroviral therapy that defined the
importance of resistance to HIV-1 pathogenesis (1994/5).
In 1996 he was appointed to the first
chair in Retrovirology at The Royal Free Hospital Medical
School. His department developed molecular virology support
within the School to quantify viral load, resistance and
subtype speciation to meets the needs of patients in the
Departments of HIV/AIDS, Haemophilia, Paediatrics and Occupational
Health in the RFH Trust. These efforts pioneered the provision
of real-time viral load and resistance measures locally
and nationally for enhanced patient care.
These efforts provided the basis for a
wealth of national and international clinical research data
to expand the understanding of HIV/AIDS.
In 1997 he discovered a high prevalence
of HIV-1 non-B viruses in local patients and using an MRC-funded
research programme has characterised over 1700 patients
to assist in their best future clinical care. In addition,
the group collaborated in team efforts with MRC, EuroSIDA
and other academic research teams to expand the understanding
of HIV/AIDS and its management.
In 2001, to maintain the integrity and excellence of this
translational research in HIV/AIDS he devolved his clinical
care and research efforts to an independent, academic, charitable
trust: The International Clinical Virology Centre (ICVC),
Buckinghamshire (www.icvc.org.uk).
The support of NHS patients care and associated research
and development continues to date. In addition, the ICVC
has undertaked training programmes for virology technical
staff, academics and health care professionals and is establishing
a clinical interface to support the needs of patients with
viral infections.
Recently he has served as the lead clinical virologist/principal
investigator in MRC Forte, ERA, PERA, Initio and TILT trials,
a series of EuroSIDA cohort studies, and the European CATCH
trials. He has contributed to over 150 peer-reviewed publications
and over 200 presentations at international peer-reviewed
conferences.
Currently Professor Loveday in the Clinical Director of
the ICVC Charitable Trust, Lead Consultant in GUM/HIV at
Brookeside Clinic, Aylesbury NHS PCT, Honorary Consultant
at St Bartholomew’s and the Royal London NHS Trust
with responsibility for HIV/AIDS therapy, on the South Buckinghamshire
register as a Flexible Career Grade GP and is Honorary Professor
to the Department of Sexual Health, Thames Valley University.

About
Dr Stephen Taylor
Dr Taylor graduated from
the University of Leicester in 1992. He trained in General
Medicine and Infectious diseases at Birmingham Heartlands
Hospital (BHH) during which time he obtained his MRCP and
Diploma in Tropical Medicine. Shortly after this he specialised
in HIV and Genitourinary Medicine.
From 1999-2002 he was awarded a 3 year
NHS R&D “Sheldon Fellowship” and became
a Clinical Research Fellow in the HPA Antiviral Susceptibility
Reference Unit within the Division of Immunity and Infection
at the University of Birmingham, training with Dr Deenan
Pillay and Pat Cane.
He obtained his PhD thesis in December
02 entitled “The Sexual Transmission of HIV”.
This focused on HIV in the male genital tract and the impact
of sexually transmitted infections and antiretroviral therapy
(ART).
The thesis also covered the pharmacokinetics
and pharmacodynamics of ART in the male genital tract and
the evolution and sexual transmission of drug resistant
HIV.
It is during this time he developed an
interest in HIV resistance and clinical pharmacology. He
has presented and published widely in these research areas
and has been an invited speaker at several International
HIV conferences
In 2003 he was appointed as a Consultant
in HIV and GU Medicine and Honorary Senior Clinical lecturer
at Birmingham Heartlands Hospital and the University of
Birmingham. In early 2005 he took over the role of lead
Consultant for the HIV service at Heartlands Hospital.
He was elected to the British HIV Association
(BHIVA) executive committee in 2003. He also sits on the
scientific committee for the International Workshop on HIV
Clinical Pharmacology.
He has been the Chief investigator and/or
Primary investigator on a number of Clinical HIV treatment
and strategy trials.
He sits on the Medical Advisory board
for HIV I.Base, and AIDs treatment update and teaches and
lectures regularly to HIV positive patient groups. From
2002-2005 he co-developed and taught on the Mediscript organised
HIV Resistance and pharmacology workshops.
In 2005 he became
one of the Founding members and Secretary of the ID Education
Association a new academic educational association for healthcare
professionals working in the field of Infectious Diseases,
Sexually Transmitted Infections and HIV/AIDS.

|